Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
1,645 institutional managers reported holding VRTX for the quarter ended Mar 31, 2026. Together they hold about 88% of shares outstanding; the top 10 hold 51%. 141 opened new positions; 134 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| Capital Group (American Funds) | 25.37M | 9.90% | $11.33B | trimmed -0.6% | ≤2013 |
| Vanguard Group | 24.29M | 9.48% | $10.84B | added +0.6% | ≤2013 |
| BlackRock | 23.97M | 9.35% | $10.70B | added +0.9% | ≤2013 |
| Capital Research Global Investors | 21.13M | 8.24% | $9.43B | added +22% | 2023 Q1 |
| State Street | 11.73M | 4.58% | $5.24B | unchanged | ≤2013 |
| Geode Capital | 6.14M | 2.40% | $2.74B | added +2.6% | ≤2013 |
| Capital International Investors | 5.13M | 2.00% | $2.29B | added +8.3% | 2024 Q4 |
| Loomis Sayles & CO L P | 4.00M | 1.56% | $1.79B | trimmed -0.7% | 2019 Q4 |
| AllianceBernstein | 3.91M | 1.53% | $1.75B | trimmed -13% | ≤2013 |
| UBS | 3.69M | 1.44% | $1.65B | added +3.7% | ≤2013 |
| Wellington Management | 3.21M | 1.25% | $1.43B | trimmed -15.9% | ≤2013 |
| Morgan Stanley | 3.19M | 1.24% | $1.42B | added +2.2% | ≤2013 |
| Bank OF America CORP /DE/ | 2.88M | 1.12% | $1.29B | trimmed -2% | ≤2013 |
| Jennison Associates LLC | 2.74M | 1.07% | $1.22B | trimmed -15.7% | ≤2013 |
| Clearbridge Investments, LLC | 2.70M | 1.05% | $1.21B | trimmed -5.6% | ≤2013 |
| Ameriprise Financial INC | 2.63M | 1.03% | $1.18B | added +16.3% | ≤2013 |
| Northern Trust | 2.56M | 1.00% | $1.14B | trimmed -0.6% | ≤2013 |
| Invesco | 2.56M | 1.00% | $1.14B | added +19% | ≤2013 |
| Goldman Sachs | 2.42M | 0.94% | $1.08B | added +37.9% | ≤2013 |
| Janus Henderson | 2.13M | 0.83% | $951.7M | trimmed -4.1% | ≤2013 |
| FMR (Fidelity) | 2.02M | 0.79% | $902.0M | trimmed -8.7% | ≤2013 |
| Legal & General Group PLC | 1.96M | 0.76% | $873.2M | trimmed -0.7% | ≤2013 |
| Charles Schwab Investment Management | 1.92M | 0.75% | $857.6M | added +3.3% | ≤2013 |
| Victory Capital Management INC | 1.89M | 0.74% | $843.2M | trimmed -43.7% | 2015 Q4 |
| T. Rowe Price | 1.76M | 0.69% | $785.9M | trimmed -22.8% | ≤2013 |
| BNY Mellon | 1.59M | 0.62% | $708.3M | added +3.9% | ≤2013 |
| Deutsche Bank AG\ | 1.54M | 0.60% | $686.6M | trimmed -13.1% | 2013 Q3 |
| Amundi | 1.47M | 0.57% | $657.4M | added +12.9% | ≤2013 |
| BNP Paribas Financial Markets | 1.27M | 0.49% | $566.1M | added +2.5% | ≤2013 |
| WCM Investment Management | 1.12M | 0.44% | $500.7M | trimmed -0.7% | 2024 Q4 |
| Royal Bank OF Canada | 1.11M | 0.43% | $496.4M | trimmed -6.9% | ≤2013 |
| Nuveen | 1.08M | 0.42% | $484.2M | added +4% | ≤2013 |
| Dimensional Fund Advisors | 989.3k | 0.39% | $441.7M | added +4.6% | ≤2013 |
| Edgewood Management | 905.1k | 0.35% | $404.1M | trimmed -14.6% | ≤2013 |
| American Century Companies INC | 813.3k | 0.32% | $363.1M | trimmed -4.2% | ≤2013 |
| Mitsubishi UFJ Asset Management CO., LTD. | 768.4k | 0.30% | $343.1M | added +5.5% | ≤2013 |
| Wells Fargo & COMPANY/MN | 745.0k | 0.29% | $332.6M | unchanged | ≤2013 |
| Swiss National Bank | 744.6k | 0.29% | $332.4M | added +6% | ≤2013 |
| Citigroup INC | 682.8k | 0.27% | $304.9M | added +26.5% | ≤2013 |
| Bellevue Group AG | 681.9k | 0.27% | $304.5M | unchanged | 2015 Q1 |
| Barclays PLC | 663.3k | 0.26% | $296.1M | trimmed -21.8% | ≤2013 |
| Hsbc Holdings PLC | 655.4k | 0.26% | $292.6M | added +4% | ≤2013 |
| Arrowstreet Capital | 639.0k | 0.25% | $285.3M | added +7.6% | 2024 Q4 |
| Sumitomo Mitsui Trust Group, INC. | 614.4k | 0.24% | $274.3M | trimmed -6.1% | ≤2013 |
| Natixis Advisors, LLC | 602.2k | 0.23% | $268.9M | added +2.4% | ≤2013 |
| Manufacturers Life Insurance Company, THE | 553.2k | 0.22% | $247.0M | trimmed -0.8% | ≤2013 |
| Neuberger Berman Group LLC | 551.5k | 0.21% | $246.2M | added +1% | ≤2013 |
| Franklin Resources | 551.1k | 0.21% | $246.1M | unchanged | ≤2013 |
| Assenagon Asset Management S.a. | 537.2k | 0.21% | $239.9M | trimmed -35.5% | 2017 Q2 |
| National Pension Service | 532.1k | 0.21% | $237.6M | unchanged | 2014 Q3 |
Largest 50 of 1,645 shown; the full ranked, searchable register is at boothcheck.com/holders/VRTX. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.