Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
348 institutional managers reported holding TGTX for the quarter ended Mar 31, 2026. Together they hold about 66% of shares outstanding; the top 10 hold 41%. 61 opened new positions; 56 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| BlackRock | 22.25M | 13.90% | $738.7M | added +1.9% | ≤2013 |
| Vanguard Group | 16.10M | 10.06% | $534.3M | added +1.5% | ≤2013 |
| State Street | 8.65M | 5.40% | $287.1M | added +2% | ≤2013 |
| Soleus Capital Management, L.p. | 4.03M | 2.52% | $133.8M | added +28.4% | 2022 Q4 |
| Geode Capital | 3.50M | 2.19% | $116.2M | added +2.8% | ≤2013 |
| Clearbridge Investments, LLC | 3.21M | 2.01% | $106.6M | trimmed -6.9% | 2024 Q4 |
| Goldman Sachs | 2.29M | 1.43% | $75.9M | added +11.5% | 2016 Q3 |
| Congress Asset Management CO | 2.17M | 1.35% | $72.0M | added +12.8% | 2025 Q4 |
| Jane Street | 2.04M | 1.28% | $67.8M | added +110.5% | 2019 Q2 |
| Citadel Advisors | 1.92M | 1.20% | $63.8M | added +90.2% | 2013 Q4 |
| Pictet Asset Management Holding SA | 1.75M | 1.09% | $58.0M | added +19.6% | 2022 Q4 |
| Hood River Capital Management LLC | 1.57M | 0.98% | $52.1M | trimmed -0.8% | 2024 Q1 |
| Two Sigma | 1.54M | 0.96% | $51.2M | added +45.4% | 2022 Q1 |
| Bank OF America CORP /DE/ | 1.46M | 0.91% | $48.5M | added +71.7% | ≤2013 |
| Nuveen | 1.45M | 0.90% | $48.0M | added +51.8% | 2019 Q2 |
| Northern Trust | 1.44M | 0.90% | $47.9M | added +1.6% | ≤2013 |
| Morgan Stanley | 1.41M | 0.88% | $46.7M | trimmed -6.3% | ≤2013 |
| Charles Schwab Investment Management | 1.30M | 0.81% | $43.0M | trimmed -1.3% | ≤2013 |
| Dimensional Fund Advisors | 1.08M | 0.68% | $36.0M | added +129.5% | 2025 Q3 |
| BNP Paribas Financial Markets | 959.3k | 0.60% | $31.8M | added +39.9% | 2014 Q1 |
| BNY Mellon | 887.3k | 0.55% | $29.5M | trimmed -1.2% | ≤2013 |
| UBS | 741.1k | 0.46% | $24.6M | trimmed -4.5% | 2013 Q3 |
| Invesco | 720.9k | 0.45% | $23.9M | trimmed -55.2% | 2020 Q3 |
| Woodline Partners LP | 715.5k | 0.45% | $23.8M | opened | 2026 Q1 |
| Principal Financial Group INC | 665.5k | 0.42% | $22.1M | trimmed -21.5% | 2019 Q3 |
| T. Rowe Price | 632.7k | 0.40% | $21.0M | added +4.4% | 2020 Q3 |
| D. E. Shaw | 590.0k | 0.37% | $19.6M | trimmed -15.7% | 2017 Q1 |
| 683 Capital Management, LLC | 590.0k | 0.37% | $19.6M | added +63.9% | 2018 Q3 |
| Occam Crest Management LP (focused) | 577.0k | 0.36% | $19.2M | added +43.7% | 2025 Q3 |
| Susquehanna International Group | 544.7k | 0.34% | $18.1M | trimmed -38.6% | ≤2013 |
| Penn Capital Management Company, LLC | 542.0k | 0.34% | $18.0M | added +0.7% | 2024 Q4 |
| Opaleye Management INC. | 535.0k | 0.33% | $17.8M | unchanged | 2023 Q3 |
| Bank OF Montreal /CAN/ | 515.3k | 0.32% | $17.1M | added +0.6% | 2024 Q1 |
| Squarepoint Ops LLC | 513.8k | 0.32% | $17.1M | trimmed -39.7% | 2022 Q3 |
| Assenagon Asset Management S.a. | 510.1k | 0.32% | $16.9M | added +218% | 2024 Q2 |
| Public Sector Pension Investment Board | 487.3k | 0.30% | $16.2M | added +3.6% | 2024 Q3 |
| Raymond James Financial INC | 426.4k | 0.27% | $14.2M | trimmed -32.3% | 2016 Q1 |
| Voya Investment Management LLC | 419.6k | 0.26% | $13.9M | added +3.6% | 2014 Q2 |
| NEW York State Common Retirement Fund | 401.8k | 0.25% | $13.3M | added +7.3% | 2014 Q4 |
| Rhumbline Advisers | 385.3k | 0.24% | $12.8M | added +1.2% | ≤2013 |
| Braidwell LP | 358.8k | 0.22% | $11.9M | opened | 2026 Q1 |
| Ameriprise Financial INC | 355.6k | 0.22% | $11.8M | trimmed -1.3% | 2023 Q1 |
| Man Group | 354.7k | 0.22% | $11.8M | trimmed -62.9% | 2024 Q4 |
| Citigroup INC | 354.0k | 0.22% | $11.8M | trimmed -26.8% | ≤2013 |
| AQR Capital | 344.2k | 0.21% | $11.4M | added +153.1% | 2023 Q1 |
| Renaissance Technologies | 340.9k | 0.21% | $11.3M | opened | 2026 Q1 |
| Wells Fargo & COMPANY/MN | 332.7k | 0.21% | $11.0M | trimmed -15.9% | ≤2013 |
| Legal & General Group PLC | 319.7k | 0.20% | $10.6M | trimmed -10.1% | 2014 Q3 |
| Bridgewater Associates | 311.4k | 0.20% | $10.3M | trimmed -33.7% | 2025 Q3 |
| Trexquant Investment LP | 311.2k | 0.19% | $10.3M | trimmed -39.3% | 2025 Q2 |
Largest 50 of 348 shown; the full ranked, searchable register is at boothcheck.com/holders/TGTX. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.