Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
313 institutional managers reported holding SUPN for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 55%. 36 opened new positions; 49 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| BlackRock | 8.80M | 15.26% | $454.6M | added +0.7% | ≤2013 |
| Vanguard Group | 6.17M | 10.71% | $319.0M | added +2% | ≤2013 |
| Millennium Management | 3.32M | 5.75% | $171.4M | added +25.6% | ≤2013 |
| Dimensional Fund Advisors | 2.31M | 4.00% | $119.2M | trimmed -14.9% | 2015 Q2 |
| State Street | 2.29M | 3.97% | $118.3M | added +3.1% | ≤2013 |
| Nomura Asset Management International INC. | 2.04M | 3.53% | $105.3M | trimmed -11.7% | 2025 Q3 |
| Armistice Capital, LLC | 1.90M | 3.29% | $98.0M | trimmed -31.4% | 2019 Q4 |
| Renaissance Technologies | 1.71M | 2.96% | $88.1M | trimmed -1.6% | 2017 Q4 |
| Geode Capital | 1.62M | 2.82% | $83.9M | added +10.2% | ≤2013 |
| Citadel Advisors | 1.49M | 2.59% | $77.2M | added +229.7% | 2020 Q4 |
| Loomis Sayles & CO L P | 1.43M | 2.47% | $73.7M | trimmed -1.6% | 2015 Q4 |
| Stephens Investment Management Group LLC | 1.35M | 2.34% | $69.8M | trimmed -3.9% | 2017 Q4 |
| Point72 | 1.32M | 2.29% | $68.1M | trimmed -41.8% | 2023 Q4 |
| Gw&k Investment Management, LLC | 1.06M | 1.83% | $54.5M | trimmed -2.4% | 2020 Q2 |
| Sofinnova Investments, INC. | 954.3k | 1.66% | $49.3M | added +72.5% | 2025 Q1 |
| Morgan Stanley | 913.9k | 1.58% | $47.2M | trimmed -15.3% | ≤2013 |
| Goldman Sachs | 856.5k | 1.49% | $44.3M | added +29.7% | 2013 Q4 |
| Bank OF America CORP /DE/ | 714.2k | 1.24% | $36.9M | added +37.2% | ≤2013 |
| Charles Schwab Investment Management | 706.0k | 1.23% | $36.5M | unchanged | ≤2013 |
| Northern Trust | 699.5k | 1.21% | $36.1M | added +4.3% | ≤2013 |
| Ashford Capital Management INC | 645.4k | 1.12% | $33.4M | added +5.4% | 2014 Q4 |
| Freestone Grove Partners LP | 641.3k | 1.11% | $33.1M | added +226.7% | 2025 Q4 |
| D. E. Shaw | 622.5k | 1.08% | $32.2M | trimmed -12.1% | 2022 Q1 |
| Assenagon Asset Management S.a. | 530.6k | 0.92% | $27.4M | opened | 2026 Q1 |
| Victory Capital Management INC | 502.4k | 0.87% | $26.0M | trimmed -4.5% | 2015 Q3 |
| Qube Research & Technologies LTD | 498.2k | 0.86% | $25.7M | added +59.8% | 2022 Q3 |
| Rice Hall James & Associates, LLC | 477.4k | 0.83% | $24.7M | added +2% | 2015 Q2 |
| Pictet Asset Management Holding SA | 450.8k | 0.78% | $23.3M | trimmed -6.8% | 2016 Q4 |
| Woodline Partners LP | 449.0k | 0.78% | $23.2M | opened | 2024 Q1 |
| Invesco | 412.7k | 0.72% | $21.3M | added +4.3% | 2015 Q2 |
| SG Americas Securities, LLC | 377.2k | 0.65% | $19.5M | added +2847% | 2023 Q3 |
| Systematic Financial Management LP | 376.1k | 0.65% | $19.4M | added +23.6% | 2024 Q3 |
| BNY Mellon | 362.4k | 0.63% | $18.7M | trimmed -2.3% | ≤2013 |
| Principal Financial Group INC | 341.1k | 0.59% | $17.6M | added +4.6% | 2015 Q2 |
| UBS | 317.0k | 0.55% | $16.4M | added +120% | ≤2013 |
| MetLife Investment Management, LLC | 304.2k | 0.53% | $15.7M | unchanged | 2017 Q4 |
| Krensavage Asset Management, LLC (focused) | 280.7k | 0.49% | $14.5M | trimmed -10.5% | 2025 Q1 |
| Aberdeen Group plc | 275.6k | 0.48% | $14.2M | added +1.5% | 2025 Q4 |
| Two Sigma | 271.2k | 0.47% | $14.0M | added +124.8% | 2022 Q1 |
| Royce & Associates | 229.9k | 0.40% | $11.9M | added +16.3% | 2024 Q4 |
| Glenmede Trust CO NA | 219.1k | 0.38% | $11.3M | trimmed -8.4% | 2025 Q4 |
| Nuveen | 216.0k | 0.38% | $11.2M | added +95% | 2018 Q1 |
| FMR (Fidelity) | 209.4k | 0.36% | $10.8M | added +68.4% | 2015 Q2 |
| Public Sector Pension Investment Board | 205.2k | 0.36% | $10.6M | added +3.4% | 2015 Q2 |
| Aristotle Capital Boston, LLC | 203.1k | 0.35% | $10.5M | trimmed -13.4% | 2019 Q2 |
| ExodusPoint | 202.1k | 0.35% | $10.4M | trimmed -11.8% | 2025 Q4 |
| Schroder Investment Management Group | 176.1k | 0.30% | $9.1M | trimmed -7.3% | 2023 Q4 |
| Ameriprise Financial INC | 173.9k | 0.30% | $9.0M | trimmed -3.9% | ≤2013 |
| Rhumbline Advisers | 169.3k | 0.29% | $8.7M | added +3% | ≤2013 |
| Axiom Investors LLC /DE | 164.0k | 0.28% | $8.5M | added +54.4% | 2022 Q4 |
Largest 50 of 313 shown; the full ranked, searchable register is at boothcheck.com/holders/SUPN. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.