Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
352 institutional managers reported holding KRYS for the quarter ended Mar 31, 2026. Together they hold about 92% of shares outstanding; the top 10 hold 63%. 68 opened new positions; 43 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| FMR (Fidelity) | 4.37M | 14.34% | $1.13B | added +0.6% | 2017 Q3 |
| BlackRock | 3.94M | 12.92% | $1.02B | unchanged | 2017 Q4 |
| Avoro Capital Advisors LLC (focused) | 2.89M | 9.47% | $744.8M | unchanged | 2021 Q4 |
| Vanguard Group | 2.84M | 9.31% | $732.6M | added +2.2% | 2017 Q4 |
| State Street | 1.31M | 4.31% | $338.9M | trimmed -2.1% | 2019 Q1 |
| Soleus Capital Management, L.p. | 1.15M | 3.78% | $297.3M | added +22.5% | 2020 Q4 |
| Capital Group (American Funds) | 824.7k | 2.70% | $212.6M | added +1.9% | 2024 Q1 |
| Redmile Group, LLC (focused) | 673.5k | 2.21% | $173.6M | trimmed -0.6% | 2018 Q4 |
| Geode Capital | 644.0k | 2.11% | $166.0M | added +5.2% | 2018 Q2 |
| Hood River Capital Management LLC | 619.6k | 2.03% | $159.7M | added +1% | 2020 Q2 |
| T. Rowe Price | 485.1k | 1.59% | $125.1M | trimmed -8.5% | 2018 Q4 |
| Bellevue Group AG | 481.8k | 1.58% | $124.2M | added +17.4% | 2021 Q4 |
| Frazier Life Sciences Management, L.p. (focused) | 481.3k | 1.58% | $124.1M | trimmed -1.5% | 2022 Q1 |
| Dimensional Fund Advisors | 469.0k | 1.54% | $120.9M | trimmed -4.9% | 2020 Q2 |
| William Blair Investment Management, LLC | 407.2k | 1.33% | $105.0M | added +8.2% | 2025 Q2 |
| First Trust Advisors LP | 350.5k | 1.15% | $90.4M | added +42.9% | 2024 Q3 |
| Janus Henderson | 266.7k | 0.87% | $68.7M | added +21.5% | 2022 Q4 |
| Bank OF America CORP /DE/ | 260.6k | 0.85% | $67.2M | added +36.6% | 2018 Q3 |
| Northern Trust | 252.5k | 0.83% | $65.1M | added +2% | 2018 Q4 |
| Invesco | 251.4k | 0.82% | $64.8M | added +318.9% | 2021 Q1 |
| Charles Schwab Investment Management | 242.0k | 0.79% | $62.4M | unchanged | 2019 Q2 |
| Goldman Sachs | 214.9k | 0.70% | $55.4M | trimmed -26.8% | 2019 Q1 |
| Morgan Stanley | 209.1k | 0.69% | $53.9M | trimmed -5.6% | 2018 Q2 |
| Braidwell LP | 182.4k | 0.60% | $47.0M | trimmed -9.7% | 2022 Q4 |
| UBS | 180.5k | 0.59% | $46.5M | trimmed -6.6% | 2018 Q4 |
| Franklin Resources | 179.3k | 0.59% | $46.2M | added +42.6% | 2021 Q1 |
| Principal Financial Group INC | 162.1k | 0.53% | $41.8M | trimmed -1.8% | 2022 Q2 |
| Raymond James Financial INC | 156.1k | 0.51% | $40.2M | added +103.9% | 2024 Q1 |
| Woodline Partners LP | 150.6k | 0.49% | $38.8M | unchanged | 2023 Q2 |
| BNY Mellon | 149.3k | 0.49% | $38.5M | trimmed -1.3% | 2018 Q4 |
| Nuveen | 143.4k | 0.47% | $37.0M | trimmed -24.2% | 2019 Q2 |
| TimesSquare Capital Management, LLC | 112.3k | 0.37% | $29.0M | added +15.3% | 2023 Q3 |
| Pictet Asset Management Holding SA | 110.7k | 0.36% | $28.5M | trimmed -29.3% | 2019 Q3 |
| Voya Investment Management LLC | 108.4k | 0.35% | $27.9M | added +5% | 2019 Q3 |
| BNP Paribas Financial Markets | 93.4k | 0.31% | $24.1M | added +72.4% | 2019 Q2 |
| Public Sector Pension Investment Board | 92.3k | 0.30% | $23.8M | added +3.3% | 2024 Q2 |
| Handelsbanken Fonder AB | 91.4k | 0.30% | $23.6M | trimmed -13.6% | 2020 Q2 |
| S Squared Technology, LLC (focused) | 86.2k | 0.28% | $22.2M | trimmed -10.4% | 2018 Q3 |
| Biondo Investment Advisors, LLC | 72.0k | 0.24% | $18.6M | added +5.7% | 2025 Q2 |
| Orbimed Advisors LLC | 69.1k | 0.23% | $17.8M | trimmed -42.3% | 2023 Q4 |
| Marshall Wace | 68.3k | 0.22% | $17.6M | trimmed -62.8% | 2024 Q4 |
| Rhumbline Advisers | 68.1k | 0.22% | $17.6M | added +2.5% | 2019 Q2 |
| C WorldWide Group Holding A/S | 67.8k | 0.22% | $17.5M | trimmed -21% | 2020 Q1 |
| ACT Capital Management, LLC | 60.5k | 0.20% | $15.6M | unchanged | 2025 Q4 |
| Legal & General Group PLC | 59.0k | 0.19% | $15.2M | trimmed -6.8% | 2019 Q2 |
| Ameriprise Financial INC | 49.8k | 0.16% | $12.8M | trimmed -4.8% | 2023 Q3 |
| SEI Investments CO | 46.6k | 0.15% | $12.0M | added +44.1% | 2019 Q2 |
| Bridgewater Associates | 46.4k | 0.15% | $12.0M | added +363% | 2025 Q3 |
| SEB Asset Management AB | 46.3k | 0.15% | $11.9M | opened | 2026 Q1 |
| Palisades Investment Partners, LLC | 45.4k | 0.15% | $11.7M | added +6.2% | 2024 Q2 |
Largest 50 of 352 shown; the full ranked, searchable register is at boothcheck.com/holders/KRYS. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.