Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
258 institutional managers reported holding ARQT for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 56%. 32 opened new positions; 52 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| Suvretta Capital Management, LLC | 12.33M | 9.53% | $290.6M | added +3% | 2023 Q1 |
| Frazier Life Sciences Management, L.p. (focused) | 9.87M | 7.63% | $232.8M | unchanged | 2022 Q1 |
| BlackRock | 9.20M | 7.11% | $216.9M | added +1.1% | 2020 Q1 |
| Rubric Capital Management LP | 8.27M | 6.39% | $195.0M | unchanged | 2022 Q3 |
| Vanguard Group | 7.75M | 5.99% | $182.7M | added +6.9% | 2020 Q1 |
| State Street | 6.30M | 4.87% | $148.4M | added +14.7% | 2020 Q1 |
| Polar Capital Holdings PLC | 5.67M | 4.38% | $133.6M | added +2% | 2020 Q1 |
| Jennison Associates LLC | 4.98M | 3.85% | $117.4M | trimmed -26.3% | 2022 Q2 |
| Gilder Gagnon Howe & CO LLC | 4.30M | 3.33% | $101.5M | trimmed -3.4% | 2024 Q1 |
| Morgan Stanley | 4.22M | 3.26% | $99.5M | trimmed -2.8% | 2020 Q1 |
| UBS | 3.57M | 2.76% | $84.1M | added +2.6% | 2020 Q1 |
| Geode Capital | 3.05M | 2.35% | $71.8M | added +10.6% | 2020 Q1 |
| D. E. Shaw | 2.50M | 1.93% | $58.8M | trimmed -7% | 2024 Q1 |
| Marshall Wace | 2.43M | 1.88% | $57.3M | added +435.4% | 2025 Q1 |
| Franklin Resources | 2.30M | 1.78% | $54.2M | added +20.9% | 2021 Q1 |
| Driehaus Capital Management LLC | 2.23M | 1.72% | $52.5M | trimmed -13.1% | 2024 Q4 |
| Bank OF America CORP /DE/ | 2.22M | 1.72% | $52.4M | added +32.7% | 2020 Q1 |
| Janus Henderson | 1.85M | 1.43% | $43.7M | added +1.3% | 2024 Q2 |
| Goldman Sachs | 1.60M | 1.24% | $37.8M | added +1.7% | 2020 Q1 |
| American Century Companies INC | 1.46M | 1.13% | $34.5M | unchanged | 2020 Q4 |
| Oberweis Asset Management INC/ | 1.37M | 1.06% | $32.2M | added +69% | 2025 Q4 |
| Pivotal bioVenture Partners Investment Advisor LLC (focused) | 1.36M | 1.05% | $32.0M | trimmed -0.8% | 2020 Q4 |
| Ensign Peak Advisors, INC | 1.24M | 0.96% | $29.3M | trimmed -34.6% | 2020 Q1 |
| Squarepoint Ops LLC | 1.10M | 0.85% | $26.0M | added +142.1% | 2023 Q3 |
| Candriam S.c.a. | 1.09M | 0.84% | $25.6M | added +35.3% | 2024 Q2 |
| Federated Hermes, INC. | 1.08M | 0.83% | $25.4M | added +20.8% | 2022 Q4 |
| Bamco INC /NY/ | 1.07M | 0.83% | $25.3M | added +112.4% | 2025 Q4 |
| Charles Schwab Investment Management | 1.01M | 0.78% | $23.9M | unchanged | 2020 Q1 |
| Gw&k Investment Management, LLC | 988.4k | 0.76% | $23.3M | trimmed -2% | 2022 Q1 |
| Northern Trust | 976.5k | 0.76% | $23.0M | added +2.2% | 2020 Q1 |
| Perpetual LTD | 909.5k | 0.70% | $21.4M | unchanged | 2025 Q1 |
| Nuveen | 902.1k | 0.70% | $21.3M | trimmed -34.7% | 2020 Q1 |
| BNP Paribas Financial Markets | 825.4k | 0.64% | $19.5M | added +16.8% | 2024 Q4 |
| MPM Bioimpact LLC (focused) | 734.0k | 0.57% | $17.3M | added +38.2% | 2025 Q4 |
| Qube Research & Technologies LTD | 724.1k | 0.56% | $17.1M | added +9.5% | 2024 Q3 |
| Aberdeen Group plc | 645.1k | 0.50% | $15.2M | added +10% | 2023 Q4 |
| Healthcare OF Ontario Pension Plan Trust Fund | 636.2k | 0.49% | $15.0M | trimmed -29.3% | 2025 Q4 |
| Nearwater Capital Markets, LTD | 607.3k | 0.47% | $14.3M | trimmed -1.3% | 2025 Q4 |
| Point72 | 590.9k | 0.46% | $13.9M | added +39% | 2024 Q3 |
| Eversept Partners, LP | 576.6k | 0.45% | $13.6M | added +32.7% | 2025 Q3 |
| Fishman JAY A LTD/MI | 566.7k | 0.44% | $13.4M | unchanged | 2022 Q2 |
| Voloridge Investment Management | 540.5k | 0.42% | $12.7M | trimmed -40.9% | 2024 Q1 |
| Manufacturers Life Insurance Company, THE | 503.9k | 0.39% | $11.9M | added +300% | 2020 Q3 |
| Capitolis Liquid Global Markets LLC | 500.0k | 0.39% | $11.8M | unchanged | 2025 Q4 |
| M&G PLC | 469.1k | 0.36% | $11.1M | opened | 2026 Q1 |
| AQR Capital | 468.3k | 0.36% | $11.0M | trimmed -6.2% | 2023 Q4 |
| Cormorant Asset Management, LP (focused) | 450.0k | 0.35% | $10.6M | trimmed -10% | 2024 Q1 |
| T. Rowe Price | 448.2k | 0.35% | $10.6M | trimmed -61.6% | 2020 Q1 |
| Renaissance Technologies | 441.0k | 0.34% | $10.4M | added +60.9% | 2025 Q4 |
| Stempoint Capital LP | 413.8k | 0.32% | $9.8M | added +84.1% | 2023 Q4 |
Largest 50 of 258 shown; the full ranked, searchable register is at boothcheck.com/holders/ARQT. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.