Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
765 institutional managers reported holding ALNY for the quarter ended Mar 31, 2026. Together they hold about 90% of shares outstanding; the top 10 hold 54%. 96 opened new positions; 166 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| FMR (Fidelity) | 14.58M | 10.62% | $4.82B | trimmed -8.3% | ≤2013 |
| Vanguard Group | 13.64M | 9.93% | $4.51B | added +0.5% | ≤2013 |
| Capital Group (American Funds) | 10.80M | 7.87% | $3.57B | trimmed -33.7% | ≤2013 |
| BlackRock | 10.44M | 7.61% | $3.46B | unchanged | ≤2013 |
| Capital Research Global Investors | 9.47M | 6.90% | $3.13B | added +39.7% | 2022 Q4 |
| T. Rowe Price Investment Management, INC. | 5.19M | 3.78% | $1.72B | added +351.1% | 2022 Q3 |
| State Street | 3.32M | 2.42% | $1.10B | added +2.9% | ≤2013 |
| Geode Capital | 2.66M | 1.94% | $880.3M | unchanged | ≤2013 |
| Baillie Gifford | 2.49M | 1.82% | $825.2M | trimmed -4.1% | ≤2013 |
| Two Sigma | 1.99M | 1.45% | $659.3M | added +223.4% | 2022 Q1 |
| Wellington Management | 1.94M | 1.41% | $640.6M | added +18.8% | 2013 Q3 |
| Dodge & Cox | 1.93M | 1.41% | $638.4M | trimmed -1.8% | 2016 Q2 |
| American Century Companies INC | 1.80M | 1.31% | $596.4M | added +21.4% | 2018 Q2 |
| T. Rowe Price | 1.43M | 1.04% | $474.1M | trimmed -15.9% | ≤2013 |
| Clearbridge Investments, LLC | 1.36M | 0.99% | $448.7M | added +127.1% | 2025 Q1 |
| Orbis Allan Gray LTD | 1.33M | 0.97% | $441.7M | trimmed -17.5% | 2024 Q2 |
| Pacer Advisors, INC. | 1.31M | 0.96% | $434.9M | added +11.4% | 2022 Q4 |
| Invesco | 1.29M | 0.94% | $427.4M | trimmed -40.4% | ≤2013 |
| UBS | 1.14M | 0.83% | $376.0M | trimmed -23.1% | ≤2013 |
| Marshall Wace | 1.10M | 0.80% | $363.8M | added +99.9% | 2024 Q3 |
| D. E. Shaw | 1.06M | 0.77% | $350.4M | added +138.3% | ≤2013 |
| Morgan Stanley | 1.00M | 0.73% | $331.8M | added +3.4% | ≤2013 |
| Bank OF America CORP /DE/ | 966.9k | 0.70% | $319.9M | added +41.1% | ≤2013 |
| Legal & General Group PLC | 934.9k | 0.68% | $309.3M | trimmed -2.8% | 2015 Q1 |
| AQR Capital | 913.1k | 0.67% | $302.1M | trimmed -0.7% | 2021 Q4 |
| Northern Trust | 858.1k | 0.63% | $283.9M | unchanged | ≤2013 |
| Qube Research & Technologies LTD | 838.2k | 0.61% | $277.3M | added +8.2% | 2023 Q3 |
| Royal Bank OF Canada | 791.5k | 0.58% | $261.9M | added +33.8% | ≤2013 |
| Deutsche Bank AG\ | 761.5k | 0.55% | $252.0M | added +7% | ≤2013 |
| Amundi | 747.5k | 0.54% | $247.4M | added +22.8% | 2017 Q1 |
| Federated Hermes, INC. | 687.8k | 0.50% | $227.6M | added +9.5% | 2022 Q4 |
| Charles Schwab Investment Management | 673.4k | 0.49% | $222.8M | added +3.9% | ≤2013 |
| Manufacturers Life Insurance Company, THE | 662.4k | 0.48% | $219.2M | added +944.5% | ≤2013 |
| Loomis Sayles & CO L P | 512.1k | 0.37% | $169.4M | added +4.7% | 2021 Q2 |
| MFS Investment Management | 496.0k | 0.36% | $164.1M | unchanged | 2025 Q3 |
| BNY Mellon | 491.2k | 0.36% | $162.5M | trimmed -2.6% | ≤2013 |
| Franklin Resources | 470.4k | 0.34% | $155.6M | trimmed -40.3% | 2019 Q1 |
| Goldman Sachs | 469.4k | 0.34% | $155.3M | added +25.3% | ≤2013 |
| BNP Paribas Financial Markets | 461.0k | 0.34% | $152.5M | trimmed -7.6% | ≤2013 |
| Millennium Management | 447.9k | 0.33% | $148.2M | added +493.8% | 2018 Q2 |
| Squarepoint Ops LLC | 426.7k | 0.31% | $141.2M | added +21.6% | 2022 Q1 |
| Raymond James Financial INC | 407.0k | 0.30% | $134.7M | added +4.7% | 2019 Q4 |
| Swiss National Bank | 387.7k | 0.28% | $128.3M | added +7.9% | ≤2013 |
| Dimensional Fund Advisors | 384.2k | 0.28% | $127.1M | added +27.3% | ≤2013 |
| First Trust Advisors LP | 382.7k | 0.28% | $126.6M | added +48.9% | 2014 Q4 |
| Wells Fargo & COMPANY/MN | 342.8k | 0.25% | $113.4M | added +33% | ≤2013 |
| Nuveen | 322.2k | 0.23% | $106.6M | trimmed -43% | 2019 Q2 |
| Sumitomo Mitsui Trust Group, INC. | 314.4k | 0.23% | $104.0M | trimmed -4.1% | 2017 Q4 |
| Congress Asset Management CO | 285.7k | 0.21% | $94.5M | added +6.1% | 2025 Q3 |
| TD Asset Management INC | 281.8k | 0.20% | $93.3M | added +4.7% | ≤2013 |
Largest 50 of 765 shown; the full ranked, searchable register is at boothcheck.com/holders/ALNY. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.