Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
326 institutional managers reported holding ACAD for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 64%. 40 opened new positions; 40 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 42.90M | 24.84% | $955.7M | unchanged | ≤2013 |
| BlackRock | 21.55M | 12.48% | $480.2M | added +3.8% | ≤2013 |
| Vanguard Group | 15.41M | 8.93% | $343.4M | added +1.7% | ≤2013 |
| State Street | 8.33M | 4.83% | $185.7M | added +5.3% | 2015 Q4 |
| RTW Investments, LP | 7.14M | 4.14% | $159.2M | unchanged | 2022 Q2 |
| Geode Capital | 3.46M | 2.01% | $77.2M | added +7% | ≤2013 |
| First Trust Advisors LP | 3.34M | 1.94% | $74.5M | added +47.3% | 2016 Q2 |
| Dimensional Fund Advisors | 3.16M | 1.83% | $70.3M | added +8% | 2019 Q3 |
| Palo Alto Investors LP | 2.87M | 1.66% | $64.0M | added +15.6% | 2016 Q1 |
| Point72 | 2.58M | 1.49% | $57.4M | trimmed -23.7% | 2014 Q2 |
| Braidwell LP | 2.47M | 1.43% | $55.1M | added +21.6% | 2025 Q3 |
| Pictet Asset Management Holding SA | 2.03M | 1.17% | $45.1M | added +31% | 2015 Q1 |
| Renaissance Technologies | 1.72M | 1.00% | $38.4M | added +12.5% | 2022 Q1 |
| Arrowstreet Capital | 1.57M | 0.91% | $35.0M | added +4.5% | 2025 Q2 |
| Goldman Sachs | 1.56M | 0.90% | $34.7M | trimmed -0.8% | ≤2013 |
| Bank OF America CORP /DE/ | 1.55M | 0.90% | $34.6M | added +27.2% | ≤2013 |
| Frazier Life Sciences Management, L.p. (focused) | 1.44M | 0.83% | $32.0M | added +10.9% | 2022 Q3 |
| Artisan Partners | 1.33M | 0.77% | $29.7M | opened | 2026 Q1 |
| Fred Alger Management, LLC | 1.28M | 0.74% | $28.5M | trimmed -18.1% | ≤2013 |
| Northern Trust | 1.27M | 0.74% | $28.4M | added +3% | ≤2013 |
| Charles Schwab Investment Management | 1.17M | 0.68% | $26.1M | unchanged | ≤2013 |
| Morgan Stanley | 1.09M | 0.63% | $24.4M | trimmed -4.3% | ≤2013 |
| Nuveen | 1.04M | 0.60% | $23.1M | trimmed -1.9% | 2019 Q2 |
| Rockefeller Capital Management L.p. | 1.03M | 0.59% | $22.9M | trimmed -7.7% | 2020 Q2 |
| MFS Investment Management | 1.02M | 0.59% | $22.7M | trimmed -4.9% | 2023 Q4 |
| Allspring Global Investments Holdings, LLC | 954.9k | 0.55% | $21.3M | added +44.9% | 2021 Q4 |
| Qube Research & Technologies LTD | 950.3k | 0.55% | $21.2M | trimmed -21% | 2022 Q4 |
| Deutsche Bank AG\ | 840.4k | 0.49% | $18.7M | added +1.4% | ≤2013 |
| Invesco | 836.5k | 0.48% | $18.6M | trimmed -1.4% | ≤2013 |
| Jane Street | 803.3k | 0.47% | $17.9M | opened | 2015 Q2 |
| Two Sigma | 775.1k | 0.45% | $17.3M | trimmed -30.7% | 2021 Q2 |
| Principal Financial Group INC | 768.2k | 0.45% | $17.1M | added +3.1% | ≤2013 |
| Logos Global Management LP | 750.0k | 0.43% | $16.7M | trimmed -11.8% | 2025 Q4 |
| BNY Mellon | 736.6k | 0.43% | $16.4M | trimmed -2.1% | ≤2013 |
| Fisher Investments | 732.9k | 0.42% | $16.3M | added +10.2% | 2023 Q4 |
| D. E. Shaw | 729.8k | 0.42% | $16.3M | trimmed -28.9% | 2018 Q2 |
| Allianz Asset Management GmbH | 706.7k | 0.41% | $15.7M | added +139.2% | 2024 Q3 |
| Millennium Management | 705.5k | 0.41% | $15.7M | added +27.4% | ≤2013 |
| Panagora Asset Management INC | 688.6k | 0.40% | $15.3M | added +1.1% | 2021 Q1 |
| Woodline Partners LP | 676.4k | 0.39% | $15.1M | opened | 2024 Q4 |
| UBS | 655.4k | 0.38% | $14.6M | trimmed -32.8% | ≤2013 |
| T. Rowe Price | 634.7k | 0.37% | $14.1M | added +3.2% | ≤2013 |
| Ameriprise Financial INC | 624.3k | 0.36% | $13.9M | trimmed -5.7% | ≤2013 |
| Citadel Advisors | 622.8k | 0.36% | $13.9M | trimmed -54.5% | ≤2013 |
| Rice Hall James & Associates, LLC | 617.5k | 0.36% | $13.8M | added +2.3% | 2020 Q1 |
| Voya Investment Management LLC | 613.8k | 0.35% | $13.7M | trimmed -4.3% | ≤2013 |
| Manufacturers Life Insurance Company, THE | 571.8k | 0.33% | $12.7M | added +7.4% | 2020 Q4 |
| AQR Capital | 527.9k | 0.31% | $11.8M | trimmed -12.7% | 2021 Q4 |
| Jupiter Asset Management LTD | 491.1k | 0.28% | $10.9M | trimmed -20.9% | 2022 Q2 |
| Public Sector Pension Investment Board | 447.9k | 0.26% | $10.0M | added +3.4% | 2025 Q1 |
Largest 50 of 326 shown; the full ranked, searchable register is at boothcheck.com/holders/ACAD. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.