Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
268 institutional managers reported holding TWST for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 72%. 62 opened new positions; 24 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| Artisan Partners | 6.37M | 10.32% | $302.8M | added +9.2% | 2023 Q1 |
| ARK Investment Management | 6.34M | 10.28% | $301.6M | trimmed -16.1% | 2019 Q2 |
| Vanguard Group | 5.81M | 9.42% | $276.4M | added +0.6% | 2018 Q4 |
| BlackRock | 5.55M | 9.00% | $264.1M | trimmed -5.8% | 2018 Q4 |
| EdgePoint Investment Group INC. (focused) | 5.38M | 8.72% | $255.9M | unchanged | 2025 Q1 |
| William Blair Investment Management, LLC | 5.27M | 8.54% | $250.6M | trimmed -11.5% | 2020 Q1 |
| State Street | 3.67M | 5.95% | $174.5M | added +1.2% | 2018 Q4 |
| Invesco | 2.17M | 3.52% | $103.3M | added +68.3% | 2019 Q2 |
| FMR (Fidelity) | 1.89M | 3.06% | $89.9M | added +2641.6% | 2018 Q4 |
| Goldman Sachs | 1.71M | 2.76% | $81.1M | added +0.5% | 2019 Q2 |
| Geode Capital | 1.52M | 2.46% | $72.3M | added +4.1% | 2018 Q4 |
| Sumitomo Mitsui Trust Group, INC. | 1.50M | 2.42% | $71.1M | trimmed -21.4% | 2020 Q1 |
| Amova Asset Management Americas, INC. | 1.50M | 2.42% | $71.1M | trimmed -21.4% | 2020 Q1 |
| Farallon Capital | 1.43M | 2.31% | $67.9M | added +18562.1% | 2024 Q2 |
| Thrivent Financial for Lutherans | 1.31M | 2.13% | $62.4M | trimmed -3.6% | 2024 Q3 |
| UBS | 1.28M | 2.07% | $60.7M | trimmed -30.5% | 2019 Q1 |
| Soleus Capital Management, L.p. | 1.23M | 1.99% | $58.3M | trimmed -34.1% | 2025 Q2 |
| Citadel Advisors | 1.22M | 1.98% | $58.0M | added +3707.9% | 2019 Q3 |
| Baillie Gifford | 1.22M | 1.97% | $57.8M | trimmed -4.8% | 2022 Q3 |
| First Light Asset Management, LLC (focused) | 878.8k | 1.42% | $41.8M | trimmed -23% | 2024 Q4 |
| Tao Capital Management LP (focused) | 828.8k | 1.34% | $39.4M | unchanged | 2019 Q4 |
| Dimensional Fund Advisors | 781.6k | 1.27% | $37.2M | trimmed -4.1% | 2020 Q4 |
| Wellington Management | 738.6k | 1.20% | $35.1M | trimmed -9.2% | 2023 Q2 |
| Balyasny Asset Management | 726.3k | 1.18% | $34.5M | added +25.4% | 2022 Q2 |
| NEW York State Common Retirement Fund | 674.0k | 1.09% | $32.0M | added +14% | 2019 Q2 |
| Point72 | 669.7k | 1.08% | $31.8M | opened | 2025 Q1 |
| Jennison Associates LLC | 605.2k | 0.98% | $28.8M | trimmed -2.2% | 2023 Q2 |
| BNP Paribas Financial Markets | 605.1k | 0.98% | $28.8M | added +45.3% | 2019 Q2 |
| Jane Street | 601.2k | 0.97% | $28.6M | opened | 2026 Q1 |
| Driehaus Capital Management LLC | 584.7k | 0.95% | $27.8M | opened | 2026 Q1 |
| Bank OF America CORP /DE/ | 584.3k | 0.95% | $27.8M | added +46.3% | 2018 Q4 |
| Morgan Stanley | 546.8k | 0.89% | $26.0M | trimmed -36.9% | 2018 Q4 |
| Charles Schwab Investment Management | 537.1k | 0.87% | $25.5M | trimmed -2.1% | 2018 Q4 |
| Northern Trust | 528.0k | 0.86% | $25.1M | added +4.6% | 2018 Q4 |
| Loomis Sayles & CO L P | 492.3k | 0.80% | $23.4M | opened | 2026 Q1 |
| Citigroup INC | 460.3k | 0.75% | $21.9M | added +14.7% | 2018 Q4 |
| Allspring Global Investments Holdings, LLC | 455.4k | 0.74% | $21.7M | opened | 2026 Q1 |
| SEI Investments CO | 354.4k | 0.57% | $16.9M | added +31.2% | 2020 Q3 |
| Millennium Management | 350.6k | 0.57% | $16.7M | trimmed -76.6% | 2019 Q2 |
| Holocene Advisors | 344.8k | 0.56% | $16.4M | opened | 2026 Q1 |
| Nuveen | 293.7k | 0.48% | $14.0M | added +1.1% | 2019 Q2 |
| IQ EQ Fund Management (IRELAND) LTD | 284.6k | 0.46% | $13.5M | trimmed -23.4% | 2024 Q2 |
| Blue Water Life Science Advisors, LP (focused) | 276.0k | 0.45% | $13.1M | trimmed -27.9% | 2025 Q4 |
| Freshford Capital Management, LLC (focused) | 259.0k | 0.42% | $12.3M | trimmed -38.4% | 2025 Q4 |
| Schonfeld Strategic Advisors | 258.6k | 0.42% | $12.3M | added +84.9% | 2022 Q2 |
| Silvercrest Asset Management Group LLC | 244.0k | 0.40% | $11.6M | trimmed -9.3% | 2023 Q2 |
| Meridiem Capital Partners LP | 239.7k | 0.39% | $11.4M | added +1030.2% | 2025 Q4 |
| Peregrine Capital Management LLC | 220.1k | 0.36% | $10.5M | trimmed -23.7% | 2025 Q2 |
| Osterweis Capital Management INC | 211.2k | 0.34% | $10.0M | trimmed -17.8% | 2025 Q4 |
| Duquesne Family Office | 206.0k | 0.33% | $9.8M | opened | 2026 Q1 |
Largest 50 of 268 shown; the full ranked, searchable register is at boothcheck.com/holders/TWST. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.