Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
252 institutional managers reported holding TVTX for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 63%. 43 opened new positions; 65 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| Janus Henderson | 11.42M | 12.43% | $339.2M | added +8.6% | 2020 Q4 |
| FMR (Fidelity) | 10.97M | 11.94% | $325.7M | added +14% | 2020 Q4 |
| BlackRock | 7.79M | 8.48% | $231.4M | trimmed -1% | 2020 Q4 |
| Vanguard Group | 6.48M | 7.05% | $192.5M | added +2.7% | 2020 Q4 |
| State Street | 4.96M | 5.40% | $147.3M | added +4.3% | 2021 Q1 |
| Armistice Capital, LLC | 4.90M | 5.33% | $145.5M | added +30.1% | 2021 Q1 |
| Perceptive Advisors LLC | 4.14M | 4.51% | $123.0M | trimmed -3.2% | 2025 Q2 |
| Nomura Asset Management International INC. | 3.27M | 3.56% | $97.1M | trimmed -14% | 2025 Q4 |
| Geode Capital | 2.37M | 2.58% | $70.4M | added +10.5% | 2020 Q4 |
| Renaissance Technologies | 1.97M | 2.14% | $58.4M | trimmed -12.5% | 2020 Q4 |
| Stephens Investment Management Group LLC | 1.80M | 1.96% | $53.4M | added +4.5% | 2025 Q3 |
| Goldman Sachs | 1.72M | 1.87% | $51.1M | trimmed -7.9% | 2020 Q4 |
| Kynam Capital Management, LP (focused) | 1.57M | 1.71% | $46.6M | added +203% | 2021 Q4 |
| Emerald Advisers, LLC | 1.56M | 1.70% | $46.2M | trimmed -2.3% | 2023 Q2 |
| Two Sigma | 1.51M | 1.64% | $44.8M | added +30.4% | 2021 Q4 |
| Rock Springs Capital Management LP | 1.48M | 1.61% | $43.9M | trimmed -33.1% | 2020 Q4 |
| Bank OF America CORP /DE/ | 1.35M | 1.46% | $39.9M | trimmed -27.3% | 2020 Q4 |
| Driehaus Capital Management LLC | 1.28M | 1.40% | $38.1M | added +42.3% | 2024 Q3 |
| MPM Bioimpact LLC (focused) | 1.13M | 1.23% | $33.7M | opened | 2026 Q1 |
| Wellington Management | 1.02M | 1.11% | $30.4M | added +27.9% | 2023 Q4 |
| UBS | 993.8k | 1.08% | $29.5M | added +55.6% | 2020 Q4 |
| Adage Capital Partners GP, L.l.c. | 977.0k | 1.06% | $29.0M | trimmed -66.6% | 2023 Q4 |
| Emerald Mutual Fund Advisers Trust | 945.0k | 1.03% | $28.1M | unchanged | 2023 Q2 |
| Nuveen | 938.6k | 1.02% | $27.9M | trimmed -5.5% | 2020 Q4 |
| Deutsche Bank AG\ | 925.9k | 1.01% | $27.5M | added +5% | 2020 Q4 |
| Fiera Capital CORP | 900.9k | 0.98% | $26.8M | added +3.1% | 2025 Q4 |
| D. E. Shaw | 836.5k | 0.91% | $24.8M | trimmed -23.6% | 2020 Q4 |
| Charles Schwab Investment Management | 790.8k | 0.86% | $23.5M | trimmed -2.2% | 2020 Q4 |
| Northern Trust | 781.4k | 0.85% | $23.2M | added +2.6% | 2020 Q4 |
| RA Capital Management, L.p. | 746.8k | 0.81% | $22.2M | opened | 2024 Q4 |
| Ensign Peak Advisors, INC | 715.7k | 0.78% | $21.3M | trimmed -11.1% | 2025 Q1 |
| Qube Research & Technologies LTD | 669.2k | 0.73% | $19.9M | added +64.7% | 2024 Q4 |
| Panagora Asset Management INC | 592.9k | 0.65% | $17.6M | added +0.9% | 2022 Q4 |
| Aberdeen Group plc | 557.1k | 0.61% | $16.5M | added +7.5% | 2024 Q4 |
| Soleus Capital Management, L.p. | 546.0k | 0.59% | $16.2M | opened | 2026 Q1 |
| Eversept Partners, LP | 542.6k | 0.59% | $16.1M | trimmed -53.8% | 2024 Q1 |
| Pictet Asset Management Holding SA | 529.8k | 0.58% | $15.7M | trimmed -0.9% | 2021 Q1 |
| Invesco | 523.7k | 0.57% | $15.6M | added +10.5% | 2020 Q4 |
| T. Rowe Price Investment Management, INC. | 520.6k | 0.57% | $15.5M | opened | 2026 Q1 |
| Legal & General Group PLC | 451.1k | 0.49% | $13.4M | trimmed -16% | 2020 Q4 |
| T. Rowe Price | 404.8k | 0.44% | $12.0M | added +2.5% | 2021 Q4 |
| Hsbc Holdings PLC | 396.9k | 0.43% | $11.8M | opened | 2026 Q1 |
| Candriam S.c.a. | 370.0k | 0.40% | $11.0M | trimmed -21% | 2025 Q1 |
| Jacobs Levy Equity Management, INC | 369.2k | 0.40% | $11.0M | added +37.3% | 2020 Q4 |
| AQR Capital | 305.4k | 0.33% | $9.1M | trimmed -13.4% | 2020 Q4 |
| Woodline Partners LP | 302.7k | 0.33% | $9.0M | added +84.3% | 2022 Q3 |
| Jane Street | 302.3k | 0.33% | $9.0M | trimmed -22.9% | 2025 Q4 |
| Morgan Stanley | 301.7k | 0.33% | $9.0M | trimmed -78.7% | 2020 Q4 |
| Loomis Sayles & CO L P | 301.5k | 0.33% | $9.0M | added +26.2% | 2025 Q1 |
| Affinity Asset Advisors, LLC | 300.0k | 0.33% | $8.9M | unchanged | 2024 Q4 |
Largest 50 of 252 shown; the full ranked, searchable register is at boothcheck.com/holders/TVTX. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.