Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
181 institutional managers reported holding TSHA for the quarter ended Mar 31, 2026. Together they hold about 72% of shares outstanding; the top 10 hold 48%. 26 opened new positions; 37 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| RA Capital Management, L.p. | 23.56M | 6.42% | $104.9M | unchanged | 2023 Q3 |
| Goldman Sachs | 22.37M | 6.10% | $99.7M | added +63.4% | 2023 Q4 |
| Avoro Capital Advisors LLC (focused) | 21.70M | 5.92% | $96.7M | unchanged | 2023 Q3 |
| BlackRock | 18.37M | 5.01% | $81.8M | trimmed -1.5% | 2020 Q3 |
| Vestal Point Capital, LP | 18.00M | 4.91% | $80.2M | added +30.9% | 2025 Q2 |
| Morgan Stanley | 17.97M | 4.90% | $80.0M | trimmed -0.6% | 2020 Q4 |
| FMR (Fidelity) | 14.32M | 3.91% | $63.8M | added +5.9% | 2020 Q3 |
| Vanguard Group | 14.04M | 3.83% | $62.6M | added +5.8% | 2020 Q3 |
| RTW Investments, LP | 13.68M | 3.73% | $60.9M | trimmed -16.6% | 2023 Q3 |
| State Street | 11.21M | 3.06% | $49.9M | added +3.9% | 2020 Q4 |
| Octagon Capital Advisors LP (focused) | 8.86M | 2.42% | $39.5M | unchanged | 2023 Q3 |
| Siren, L.l.c. | 8.83M | 2.41% | $39.3M | trimmed -12.8% | 2024 Q3 |
| Polar Capital Holdings PLC | 5.65M | 1.54% | $25.2M | trimmed -28.7% | 2023 Q3 |
| Geode Capital | 5.53M | 1.51% | $24.6M | added +2.7% | 2020 Q4 |
| D. E. Shaw | 4.43M | 1.21% | $19.7M | added +10.3% | 2025 Q2 |
| Baker Bros. Advisors LP | 4.00M | 1.09% | $17.8M | unchanged | 2023 Q3 |
| Millennium Management | 3.28M | 0.90% | $14.6M | added +3.2% | 2020 Q3 |
| Casdin Capital, LLC (focused) | 3.25M | 0.89% | $14.5M | added +116.7% | 2025 Q4 |
| Adar1 Capital Management, LLC | 2.98M | 0.81% | $13.3M | added +19.4% | 2023 Q4 |
| Healthcare OF Ontario Pension Plan Trust Fund | 2.88M | 0.79% | $12.8M | trimmed -22.5% | 2025 Q4 |
| Barclays PLC | 2.81M | 0.77% | $12.5M | trimmed -49.2% | 2024 Q2 |
| Deerfield Management Company, L.p. | 2.72M | 0.74% | $12.1M | unchanged | 2025 Q2 |
| SG Americas Securities, LLC | 2.18M | 0.59% | $9.7M | added +178.5% | 2024 Q3 |
| Rice Hall James & Associates, LLC | 1.94M | 0.53% | $8.7M | added +53% | 2025 Q3 |
| Northern Trust | 1.81M | 0.49% | $8.1M | added +46.6% | 2020 Q4 |
| Charles Schwab Investment Management | 1.81M | 0.49% | $8.1M | trimmed -5% | 2020 Q4 |
| B Group, INC. (focused) | 1.80M | 0.49% | $8.0M | unchanged | 2024 Q4 |
| Bank OF America CORP /DE/ | 1.68M | 0.46% | $7.5M | added +45.5% | 2020 Q4 |
| Palo Alto Investors LP | 1.39M | 0.38% | $6.2M | added +17.6% | 2023 Q4 |
| Aberdeen Group plc | 1.02M | 0.28% | $4.5M | unchanged | 2025 Q4 |
| Affinity Asset Advisors, LLC | 1.00M | 0.27% | $4.5M | trimmed -69.7% | 2025 Q2 |
| Granahan Investment Management, LLC | 883.2k | 0.24% | $3.9M | added +25.5% | 2024 Q2 |
| Quantum Private Wealth, LLC | 849.2k | 0.23% | $3.8M | added +3.6% | 2021 Q4 |
| UBS | 783.5k | 0.21% | $3.5M | added +42.3% | 2020 Q3 |
| Two Sigma | 742.1k | 0.20% | $3.3M | added +111.3% | 2024 Q4 |
| GordonMD Global Investments LP (focused) | 737.5k | 0.20% | $3.3M | trimmed -44.6% | 2025 Q4 |
| Sands Capital | 724.9k | 0.20% | $3.2M | unchanged | 2020 Q3 |
| Wellington Management | 626.4k | 0.17% | $2.8M | trimmed -11.9% | 2024 Q3 |
| Seven Fleet Capital Management LP | 625.7k | 0.17% | $2.8M | added +274.2% | 2025 Q4 |
| BNY Mellon | 608.1k | 0.17% | $2.7M | trimmed -2.6% | 2023 Q3 |
| Nuveen | 549.2k | 0.15% | $2.4M | added +0.7% | 2024 Q2 |
| Woodline Partners LP | 513.8k | 0.14% | $2.3M | added +2.8% | 2024 Q2 |
| Voya Investment Management LLC | 512.0k | 0.14% | $2.3M | added +134.7% | 2024 Q2 |
| Dimensional Fund Advisors | 490.5k | 0.13% | $2.2M | unchanged | 2025 Q3 |
| Jefferies Financial Group INC. | 479.0k | 0.13% | $2.1M | added +1816% | 2024 Q1 |
| Point72 | 461.9k | 0.13% | $2.1M | trimmed -88.1% | 2025 Q1 |
| Acuta Capital Partners, LLC (focused) | 439.5k | 0.12% | $2.0M | trimmed -3.4% | 2023 Q3 |
| Renaissance Technologies | 413.2k | 0.11% | $1.8M | added +141.5% | 2022 Q1 |
| Citadel Advisors | 411.1k | 0.11% | $1.8M | trimmed -77.8% | 2021 Q4 |
| Squarepoint Ops LLC | 410.3k | 0.11% | $1.8M | trimmed -13% | 2023 Q2 |
Largest 50 of 181 shown; the full ranked, searchable register is at boothcheck.com/holders/TSHA. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.