Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
338 institutional managers reported holding PTCT for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 66%. 52 opened new positions; 48 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| BlackRock | 12.95M | 15.69% | $881.9M | added +1.3% | 2013 Q3 |
| Vanguard Group | 9.16M | 11.10% | $624.1M | added +4% | 2013 Q3 |
| RTW Investments, LP | 7.75M | 9.39% | $527.6M | unchanged | 2016 Q4 |
| Janus Henderson | 7.19M | 8.72% | $489.9M | added +48.3% | 2019 Q1 |
| State Street | 4.35M | 5.27% | $296.0M | added +3.3% | 2013 Q3 |
| Wellington Management | 3.94M | 4.78% | $268.5M | added +1.9% | 2013 Q3 |
| Toronto Dominion Bank | 3.03M | 3.67% | $206.1M | trimmed -26.9% | 2024 Q4 |
| Geode Capital | 2.21M | 2.68% | $150.5M | added +9.6% | 2013 Q3 |
| Armistice Capital, LLC | 2.07M | 2.51% | $141.3M | trimmed -26% | 2018 Q4 |
| Bank OF America CORP /DE/ | 1.89M | 2.29% | $128.5M | added +31.8% | 2013 Q4 |
| Hood River Capital Management LLC | 1.66M | 2.02% | $113.4M | added +65.9% | 2025 Q1 |
| D. E. Shaw | 1.64M | 1.99% | $111.7M | trimmed -6% | 2015 Q3 |
| FMR (Fidelity) | 1.53M | 1.85% | $104.1M | trimmed -9.1% | 2013 Q3 |
| Tang Capital Management LLC | 1.50M | 1.82% | $102.2M | unchanged | 2023 Q4 |
| UBS | 1.49M | 1.81% | $101.6M | added +36% | 2013 Q3 |
| Jefferies Financial Group INC. | 1.35M | 1.64% | $92.2M | trimmed -18.3% | 2025 Q3 |
| BNP Paribas Financial Markets | 1.23M | 1.49% | $83.9M | trimmed -16.5% | 2014 Q1 |
| Pictet Asset Management Holding SA | 1.18M | 1.43% | $80.6M | added +20.9% | 2022 Q2 |
| Franklin Resources | 1.12M | 1.36% | $76.4M | trimmed -12.8% | 2018 Q3 |
| Driehaus Capital Management LLC | 1.02M | 1.23% | $69.2M | trimmed -10.6% | 2024 Q4 |
| Palo Alto Investors LP | 921.6k | 1.12% | $62.8M | added +2% | 2024 Q3 |
| Dimensional Fund Advisors | 890.7k | 1.08% | $60.7M | added +42% | 2024 Q4 |
| SG Americas Securities, LLC | 879.7k | 1.07% | $59.9M | trimmed -1.7% | 2024 Q3 |
| Invesco | 865.5k | 1.05% | $58.9M | added +99.3% | 2016 Q4 |
| Goldman Sachs | 827.6k | 1.00% | $56.4M | trimmed -19.1% | 2014 Q3 |
| Northern Trust | 806.3k | 0.98% | $54.9M | added +4.8% | 2013 Q3 |
| Woodline Partners LP | 745.0k | 0.90% | $50.7M | added +30.3% | 2025 Q3 |
| Charles Schwab Investment Management | 731.6k | 0.89% | $49.8M | unchanged | 2013 Q3 |
| Jupiter Asset Management LTD | 711.5k | 0.86% | $48.5M | added +97% | 2025 Q2 |
| Morgan Stanley | 674.1k | 0.82% | $45.9M | trimmed -25.5% | 2013 Q4 |
| Nuveen | 667.0k | 0.81% | $45.4M | trimmed -4.6% | 2019 Q2 |
| Boston Partners | 647.5k | 0.79% | $44.1M | added +32.7% | 2025 Q3 |
| Lord, Abbett & CO. LLC | 617.1k | 0.75% | $42.0M | trimmed -1.6% | 2025 Q2 |
| Ensign Peak Advisors, INC | 582.3k | 0.71% | $39.7M | added +107.5% | 2019 Q4 |
| Renaissance Technologies | 533.3k | 0.65% | $36.3M | trimmed -12.2% | 2023 Q3 |
| BNY Mellon | 522.8k | 0.63% | $35.6M | added +1.6% | 2013 Q3 |
| Principal Financial Group INC | 515.0k | 0.62% | $35.1M | added +7.5% | 2017 Q4 |
| Qube Research & Technologies LTD | 513.8k | 0.62% | $35.0M | opened | 2023 Q3 |
| Loomis Sayles & CO L P | 493.6k | 0.60% | $33.6M | opened | 2026 Q1 |
| T. Rowe Price | 475.1k | 0.58% | $32.4M | added +3.3% | 2018 Q2 |
| Marshall Wace | 460.6k | 0.56% | $31.4M | added +85.9% | 2025 Q1 |
| Balyasny Asset Management | 460.6k | 0.56% | $31.4M | opened | 2025 Q3 |
| Parkman Healthcare Partners LLC | 431.4k | 0.52% | $29.4M | added +169.3% | 2024 Q3 |
| Manufacturers Life Insurance Company, THE | 425.2k | 0.52% | $29.0M | unchanged | 2013 Q3 |
| Citadel Advisors | 385.2k | 0.47% | $26.2M | trimmed -66.6% | 2014 Q1 |
| Rockefeller Capital Management L.p. | 384.7k | 0.47% | $26.2M | trimmed -5.1% | 2021 Q2 |
| Defilade Capital Management, L.p. (focused) | 376.2k | 0.46% | $25.6M | opened | 2026 Q1 |
| Panagora Asset Management INC | 351.4k | 0.43% | $23.9M | trimmed -2.4% | 2018 Q1 |
| Mackenzie Financial CORP | 345.7k | 0.42% | $23.5M | added +45.9% | 2024 Q2 |
| Legal & General Group PLC | 343.4k | 0.42% | $23.4M | trimmed -6.2% | 2014 Q3 |
Largest 50 of 338 shown; the full ranked, searchable register is at boothcheck.com/holders/PTCT. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.