Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
272 institutional managers reported holding IOVA for the quarter ended Mar 31, 2026. Together they hold about 64% of shares outstanding; the top 10 hold 40%. 57 opened new positions; 43 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| BlackRock | 31.08M | 7.43% | $109.1M | added +5.3% | 2017 Q2 |
| Vanguard Group | 30.93M | 7.39% | $108.6M | added +13.6% | 2017 Q2 |
| MHR Fund Management LLC (focused) | 28.97M | 6.92% | $101.7M | unchanged | 2022 Q4 |
| State Street | 17.45M | 4.17% | $61.2M | trimmed -13.5% | 2017 Q2 |
| Two Sigma | 13.69M | 3.27% | $48.0M | added +211.2% | 2024 Q2 |
| Millennium Management | 9.41M | 2.25% | $33.0M | added +43% | 2021 Q4 |
| Goldman Sachs | 8.76M | 2.09% | $30.7M | added +1.8% | 2017 Q2 |
| Geode Capital | 8.57M | 2.05% | $30.1M | added +7.3% | 2017 Q2 |
| Invenomic Capital Management LP | 8.50M | 2.03% | $29.8M | trimmed -29% | 2025 Q1 |
| Bank OF America CORP /DE/ | 8.49M | 2.03% | $29.8M | trimmed -40.5% | 2017 Q2 |
| D. E. Shaw | 8.02M | 1.92% | $28.1M | added +109.3% | 2019 Q4 |
| Palo Alto Investors LP | 6.35M | 1.52% | $22.3M | trimmed -10.8% | 2023 Q4 |
| Morgan Stanley | 6.20M | 1.48% | $21.8M | trimmed -32.5% | 2017 Q2 |
| Jane Street | 4.17M | 1.00% | $14.7M | added +16.5% | 2019 Q2 |
| Nuveen | 3.66M | 0.88% | $12.9M | added +164.4% | 2019 Q1 |
| HRT Financial LP | 3.49M | 0.83% | $12.2M | trimmed -20% | 2025 Q1 |
| T. Rowe Price | 3.17M | 0.76% | $11.1M | added +165.7% | 2018 Q1 |
| Susquehanna International Group | 3.00M | 0.72% | $10.5M | trimmed -39.4% | 2019 Q2 |
| Northern Trust | 2.88M | 0.69% | $10.1M | added +11.5% | 2017 Q2 |
| Charles Schwab Investment Management | 2.78M | 0.67% | $9.8M | added +1.1% | 2017 Q2 |
| Dimensional Fund Advisors | 2.65M | 0.63% | $9.3M | added +71.9% | 2018 Q3 |
| Citadel Advisors | 2.61M | 0.62% | $9.2M | trimmed -16.9% | 2017 Q3 |
| UBS | 2.39M | 0.57% | $8.4M | added +93.8% | 2017 Q2 |
| Marshall Wace | 2.36M | 0.56% | $8.3M | opened | 2026 Q1 |
| Long Focus Capital Management, LLC | 2.10M | 0.50% | $7.4M | trimmed -75.6% | 2021 Q4 |
| Wells Fargo & COMPANY/MN | 2.07M | 0.49% | $7.3M | added +3.9% | 2017 Q2 |
| Orion Investment CO | 2.07M | 0.49% | $7.3M | added +11.2% | 2024 Q2 |
| Rhenman & Partners Asset Management AB | 2.06M | 0.49% | $7.2M | added +28.8% | 2017 Q2 |
| Knott David M Jr | 1.60M | 0.38% | $5.6M | opened | 2026 Q1 |
| Rice Hall James & Associates, LLC | 1.51M | 0.36% | $5.3M | added +6.3% | 2020 Q1 |
| B Group, INC. (focused) | 1.50M | 0.36% | $5.3M | unchanged | 2024 Q4 |
| Invesco | 1.42M | 0.34% | $5.0M | added +13.6% | 2019 Q2 |
| Woodline Partners LP | 1.29M | 0.31% | $4.5M | added +127.6% | 2023 Q3 |
| C WorldWide Group Holding A/S | 1.26M | 0.30% | $4.4M | unchanged | 2022 Q2 |
| Mirador Capital Partners LP | 1.07M | 0.26% | $3.8M | added +3.7% | 2025 Q3 |
| Squarepoint Ops LLC | 1.03M | 0.25% | $3.6M | added +4028.5% | 2024 Q2 |
| Voloridge Investment Management | 1.02M | 0.24% | $3.6M | opened | 2026 Q1 |
| Soleus Capital Management, L.p. | 1.00M | 0.24% | $3.5M | opened | 2022 Q2 |
| BNY Mellon | 956.8k | 0.23% | $3.4M | unchanged | 2017 Q2 |
| Susquehanna Portfolio Strategies, LLC | 914.4k | 0.22% | $3.2M | unchanged | 2025 Q3 |
| Sector Gamma AS (focused) | 900.0k | 0.21% | $3.2M | opened | 2026 Q1 |
| Deutsche Bank AG\ | 735.0k | 0.18% | $2.6M | added +6.5% | 2017 Q2 |
| QVT Financial LP | 678.6k | 0.16% | $2.4M | unchanged | 2017 Q2 |
| Healthcare OF Ontario Pension Plan Trust Fund | 628.5k | 0.15% | $2.2M | unchanged | 2025 Q3 |
| Royal Bank OF Canada | 625.0k | 0.15% | $2.2M | added +2.7% | 2017 Q2 |
| AQR Capital | 624.2k | 0.15% | $2.2M | added +464.4% | 2024 Q1 |
| Swiss National Bank | 606.5k | 0.14% | $2.1M | unchanged | 2017 Q2 |
| Group ONE Trading LLC | 595.8k | 0.14% | $2.1M | added +253.2% | 2020 Q3 |
| LPL Financial LLC | 569.2k | 0.14% | $2.0M | trimmed -8.6% | 2020 Q3 |
| GSA Capital Partners LLP | 557.1k | 0.13% | $2.0M | trimmed -36.2% | 2024 Q1 |
Largest 50 of 272 shown; the full ranked, searchable register is at boothcheck.com/holders/IOVA. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.