Mar 31, 2026 filings. Quarterly 13F reports arrive up to 45 days after quarter end; this register is filed through May 29, 2026.
222 institutional managers reported holding AGIO for the quarter ended Mar 31, 2026. Reported positions total over 95% of shares outstanding; the top 10 hold 59%. 30 opened new positions; 41 closed out. Complete ranked register from SEC 13F filings.
| manager | shares | % out | value (Mar 31, 2026 close) | change | held since |
|---|---|---|---|---|---|
| BlackRock | 5.75M | 9.79% | $194.7M | added +9.9% | 2013 Q3 |
| Vanguard Group | 5.72M | 9.73% | $193.5M | added +2.3% | 2013 Q3 |
| Farallon Capital | 5.68M | 9.67% | $192.3M | added +10.2% | 2019 Q4 |
| State Street | 3.36M | 5.72% | $113.8M | added +8.3% | 2013 Q3 |
| Armistice Capital, LLC | 2.72M | 4.62% | $91.9M | trimmed -10.5% | 2022 Q3 |
| Erste Asset Management GmbH | 2.70M | 4.60% | $91.5M | trimmed -3.6% | 2018 Q4 |
| D. E. Shaw | 2.68M | 4.56% | $90.7M | added +45.9% | 2017 Q4 |
| Lynx1 Capital Management LP (focused) | 2.61M | 4.44% | $88.3M | added +3179.9% | 2025 Q4 |
| BNP Paribas Financial Markets | 1.91M | 3.25% | $64.6M | added +19% | 2014 Q1 |
| Nomura Asset Management International INC. | 1.50M | 2.56% | $50.9M | trimmed -12.3% | 2025 Q4 |
| T. Rowe Price Investment Management, INC. | 1.49M | 2.53% | $50.4M | added +166799.1% | 2025 Q4 |
| Geode Capital | 1.47M | 2.50% | $49.7M | added +3.8% | 2013 Q3 |
| Susquehanna International Group | 1.34M | 2.29% | $45.5M | added +17.7% | 2017 Q3 |
| MPM Bioimpact LLC (focused) | 1.31M | 2.22% | $44.2M | unchanged | 2025 Q4 |
| Frazier Life Sciences Management, L.p. (focused) | 1.26M | 2.14% | $42.5M | trimmed -1.8% | 2023 Q3 |
| Gw&k Investment Management, LLC | 1.21M | 2.07% | $41.1M | added +0.6% | 2024 Q1 |
| Dimensional Fund Advisors | 1.15M | 1.96% | $39.0M | added +14.7% | 2018 Q1 |
| Morgan Stanley | 967.5k | 1.65% | $32.7M | added +8.2% | 2013 Q3 |
| Goldman Sachs | 805.8k | 1.37% | $27.3M | trimmed -22.1% | 2013 Q4 |
| Rock Springs Capital Management LP | 799.2k | 1.36% | $27.0M | unchanged | 2019 Q1 |
| Nuveen | 722.3k | 1.23% | $24.4M | added +142.5% | 2019 Q2 |
| Jane Street | 685.2k | 1.17% | $23.2M | trimmed -38.9% | 2018 Q2 |
| Wellington Management | 641.5k | 1.09% | $21.7M | added +7.3% | 2013 Q3 |
| Citadel Advisors | 619.6k | 1.05% | $21.0M | trimmed -54.1% | 2016 Q3 |
| SCS Capital Management LLC | 612.9k | 1.04% | $20.7M | added +2.4% | 2025 Q1 |
| Foresite Capital Management VI LLC (focused) | 525.0k | 0.89% | $17.8M | trimmed -0.9% | 2025 Q4 |
| Northern Trust | 509.3k | 0.87% | $17.2M | trimmed -0.5% | 2013 Q3 |
| Bank OF America CORP /DE/ | 507.9k | 0.86% | $17.2M | trimmed -5.8% | 2013 Q4 |
| Artisan Partners | 481.5k | 0.82% | $16.3M | trimmed -4.6% | 2024 Q2 |
| Charles Schwab Investment Management | 477.0k | 0.81% | $16.1M | trimmed -1.2% | 2013 Q3 |
| Connor, Clark & Lunn Investment Management LTD. | 450.1k | 0.77% | $15.2M | trimmed -20% | 2021 Q1 |
| Vestal Point Capital, LP | 450.0k | 0.77% | $15.2M | added +38.5% | 2025 Q3 |
| Marshall Wace | 448.1k | 0.76% | $15.2M | added +26.7% | 2023 Q3 |
| Legal & General Group PLC | 423.9k | 0.72% | $14.3M | added +29.2% | 2014 Q3 |
| ArrowMark Colorado Holdings LLC | 403.6k | 0.69% | $13.7M | trimmed -13.4% | 2015 Q4 |
| Parkman Healthcare Partners LLC | 403.5k | 0.69% | $13.7M | added +305.1% | 2025 Q3 |
| T. Rowe Price | 298.8k | 0.51% | $10.1M | trimmed -53.2% | 2014 Q2 |
| Kennedy Capital Management LLC | 275.5k | 0.47% | $9.3M | added +319.6% | 2024 Q1 |
| Algert Global LLC | 268.4k | 0.46% | $9.1M | trimmed -35.2% | 2024 Q1 |
| Two Sigma | 251.6k | 0.43% | $8.5M | trimmed -16.2% | 2025 Q3 |
| Arrowstreet Capital | 250.5k | 0.43% | $8.5M | opened | 2026 Q1 |
| UBS | 243.2k | 0.41% | $8.2M | added +4.1% | 2013 Q3 |
| Panagora Asset Management INC | 238.5k | 0.41% | $8.1M | added +198.7% | 2024 Q2 |
| Palo Alto Investors LP | 213.6k | 0.36% | $7.2M | added +0.5% | 2025 Q1 |
| Seven Fleet Capital Management LP | 209.5k | 0.36% | $7.1M | added +560.2% | 2025 Q4 |
| Squarepoint Ops LLC | 208.9k | 0.35% | $7.1M | added +71.6% | 2025 Q4 |
| Schonfeld Strategic Advisors | 200.1k | 0.34% | $6.8M | opened | 2026 Q1 |
| Eversept Partners, LP | 200.0k | 0.34% | $6.8M | opened | 2026 Q1 |
| HRT Financial LP | 195.4k | 0.33% | $6.6M | added +33.4% | 2025 Q4 |
| Qube Research & Technologies LTD | 187.7k | 0.32% | $6.3M | trimmed -50.4% | 2023 Q4 |
Largest 50 of 222 shown; the full ranked, searchable register is at boothcheck.com/holders/AGIO. Related filers are grouped using the filings' own included-manager declarations. Historically, several managers opening new positions in the same quarter said almost nothing about the quarter that followed (59,118 cases since 2013). A filed record, not a forecast. Nothing here is investment advice.